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The spleen can also become injured or rupture immediately after a hard hit to the abdomen, a rib fracture, or other accident. If your spleen enlarges too much, it can rupture. The same 2016 research review above showed that an enlargement of the spleen that leads to the destruction of too many blood cells is a condition called hypersplenism.Īn enlarged spleen may not cause symptoms at first. It may accidentally filter out normal red blood cells and platelets, leaving fewer healthy blood cells in your body. When your spleen enlarges, it can’t filter your blood as efficiently as it once did. a cyst, abscess, or benign tumor in the spleen.inflammatory disorders, such as lupus, rheumatoid arthritis, or sarcoidosis.a blood clot in a vein of the spleen or liver.metabolic disorders like Gaucher’s disease and Niemann-Pick disease.

blood cancers such as Hodgkin’s disease, leukemia, and lymphoma.

bacterial, viral, and parasitic infections such as syphilis, tuberculosis, endocarditis, mononucleosis (mono), and malaria.

Other conditions that cause an enlarged spleen include: An excess destruction of blood cells, for example, can overwork the spleen, and cause it to enlarge.

Many different conditions can cause the spleen to enlarge, especially diseases that cause blood cells to break down too quickly.